abstract：:Weekly adalimumab dosing is used to treat juvenile idiopathic arthritis (JIA), uveitis, and other pediatric rheumatic diseases, but the safety of such dosing has not previously been studied. A retrospective chart review was conducted to assess the safety of weekly adalimumab. Demographic and clinical data were collect...

journal_title：Clinical rheumatology

authors： Correll CK,Bullock DR,Cafferty RM,Vehe RK

更新日期：2018-02-01 00:00:00

abstract：:Juvenile systemic lupus erythematosus (JSLE) is a multi-system autoimmune inflammatory disease. Generally, 60% of patients will develop lupus nephritis (LN); thus, early recognition and treatment is associated with better outcome. Interleukin 22 (IL-22) is involved in tissue inflammation and is regulated by interleuki...

journal_title：Clinical rheumatology

authors： Badr AMM,Farag Y,Abdelshafy M,Riad NM

更新日期：2018-02-01 00:00:00

abstract：:The objective of the study is to determine the risk factors for the development of reactive arthritis (ReA) and examine the factors associated with the persistence of symptoms. Patients with a new diagnosis of ReA and controls with a gastrointestinal (GI), urogenital, or sexually transmitted infection in the 3-6 month...

journal_title：Clinical rheumatology

authors： Garcia Ferrer HR,Azan A,Iraheta I,Von Feldt J,Espinoza LR,Manasson J,Scher JU,Garcia Kutzbach A,Ogdie A

更新日期：2018-02-01 00:00:00

abstract：:Statin-induced necrotising autoimmune myopathy (NAM) is a rare but disabling complication of statin therapy. Data regarding treatment and outcomes in these patients is sparse. We retrospectively identified those patients with a diagnosis of statin-induced NAM who were managed in a single-tertiary referral centre from ...

journal_title：Clinical rheumatology

authors： Waters MJ,Limaye V

更新日期：2018-02-01 00:00:00

abstract：:IL-34 is a pleiotropic cytokine, which is a key regulator of monocytes/macrophages and might participate in the pathogenesis of RA. In this study, we aimed to explore the effect of IL-34 on the monocyte-like cell line THP-1 and the quantitative variation of Th17 cells in THP-1 and RA CD4+T cells coculture system. CD4+...

journal_title：Clinical rheumatology

authors： Wang B,Tang Y,Sun X,Ouyang X,Li H,Wei J,Zhang Y,Li X

更新日期：2018-01-01 00:00:00

abstract：:We aimed to investigate the possible effects of thioredoxin 1 (Trx1) on the proliferation and apoptosis of rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs) and elucidate the possible mechanisms involved. We investigated the distribution and expression of Trx1 in synovial tissues from RA and osteoarthritis (...

journal_title：Clinical rheumatology

authors： Lu T,Zong M,Fan S,Lu Y,Yu S,Fan L

更新日期：2018-01-01 00:00:00

abstract：:Intussusception is characterized by one segment of the gastrointestinal tract telescoping into the lumen of the adjacent segment; it is rarely reported in systemic lupus erythematosus (SLE), and the condition can be threatening. Only four cases of intussusception with SLE have been reported in literature. Here, we des...

journal_title：Clinical rheumatology

authors： Zhou JF,Liu SY,Zheng Y

更新日期：2018-01-01 00:00:00

abstract：:We reviewed three cases of systemic lupus erythematosus (SLE) in children with mesenteric vasculitis (LMV) as initial presentation and analysed their clinical characteristics to improve the understanding of this disease. Three patients with SLE were admitted to our hospital and initially presented with gastrointestina...

journal_title：Clinical rheumatology

authors： Liu Y,Zhu J,Lai JM,Sun XF,Hou J,Zhou ZX,Yuan XY

更新日期：2018-01-01 00:00:00

abstract：:Patients with Rheumatic diseases (RDs) are at an increased risk of malignancies compared with the general population. The aim of this study was to examine the relative frequency of several cancers in a single homogeneous cohort of patients with different RDs. Patients diagnosed with rheumatoid arthritis (RA), Ankylosi...

journal_title：Clinical rheumatology

authors： Wang HL,Zhou YM,Zhu GZ,Yang Z,Hua BJ

更新日期：2018-01-01 00:00:00

abstract：:We investigated the all-inclusive echocardiographic features in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) within 3 months before and after diagnosis. We reviewed the medical records of 89 AAV patients taking echocardiography and 35 age- and gender-matched controls. We collect...

journal_title：Clinical rheumatology

authors： Ahn SS,Park ES,Jung SM,Song JJ,Park YB,Lee SW

更新日期：2017-12-01 00:00:00

abstract：:The objective of this study is to determine whether meniscal extrusion (ME) of the medial meniscus on ultrasonography affects knee osteoarthritis (KOA) progression during 3-year follow-up. Two hundred seventy volunteers (70 men, 200 women; mean age 60.5 years) participated. Weight-bearing radiographs were evaluated. A...

journal_title：Clinical rheumatology

authors： Chiba D,Maeda S,Sasaki E,Ota S,Nakaji S,Tsuda E,Ishibashi Y

更新日期：2017-11-01 00:00:00

abstract：:The objective of this study was to characterise the peripheral arthritis of spondyloarthritis (pSpA) excluding psoriatic-, inflammatory enteropathy-related, post-infectious reactive-SpA and arthritis associated with axial SpA/ankylosing spondylitis (axSpA/AS). Patients presenting with the clinical features of the broa...

journal_title：Clinical rheumatology

authors： Malaviya AN,Agrawal N,Patil NS

更新日期：2017-11-01 00:00:00

abstract：:To analyse efficacy and safety of tocilizumab in patients with rheumatoid arthritis (RA) and an inadequate response to conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs) and/or tumour necrosis factor (TNF) inhibitors of the Swiss and Austrian patients from the ACT-SURE study. This is a sub-analys...

journal_title：Clinical rheumatology

authors： Mueller RB,Graninger W,Sidiropoulos P,Goger C,von Kempis J

更新日期：2017-10-01 00:00:00

abstract：:Monocytes are an important component in the innate immune system. However, studies to date have failed to conclude whether their levels are altered in patients with systemic lupus erythematosus (SLE). We applied the cytodiff counting method and comprehensively measured the circulating levels of distinct white blood ce...

journal_title：Clinical rheumatology

authors： Wu Z,Zhang S,Zhao L,Fei Y,Wang L,Li J,Wen X,Zeng X,Zhang F,Li Y

更新日期：2017-10-01 00:00:00

abstract：:The aim of this study was to evaluate clinical remission and MDA in PsA patients who started TNF-inhibitors (TNFi) treatment with a 2-year follow-up. Concomitant therapies as well as comorbidities were assessed. Level of concordance of clinimetric indices and the potential predictive factors of remission/MDA were also...

journal_title：Clinical rheumatology

authors： Chimenti MS,Triggianese P,Conigliaro P,Tonelli M,Gigliucci G,Novelli L,Teoli M,Perricone R

更新日期：2017-10-01 00:00:00

abstract：:Knee osteoarthritis (KOA) is a common degenerative joint disease causing pain, stiffness, reduced motion, swelling, crepitus, and disability. Several inflammatory markers and cartilage degradation products can be used as biomarkers in OA. The key factors of bone metabolism in normal joint bone, dickkopf-1 (DKK1) and o...

journal_title：Clinical rheumatology

authors： Min S,Wang C,Lu W,Xu Z,Shi D,Chen D,Teng H,Jiang Q

更新日期：2017-10-01 00:00:00

abstract：:This study aimed to investigate the multiple values of 18F-FDG PET/CT in detecting malignant tumors, evaluating myopathy, and determining interstitial lung disease in patients with idiopathic inflammatory myopathy (IIM). We retrospectively analyzed the data of 38 patients who were examined by 18F-FDG PET/CT and eventu...

journal_title：Clinical rheumatology

authors： Li Y,Zhou Y,Wang Q

更新日期：2017-10-01 00:00:00

abstract：:This study aimed to compare the diagnostic value of ultrasonography to conventional radiography in detecting osteophytes and erosions in the midfoot joints in patients suffering from inflammatory and non-inflammatory joint disease. Patients with current foot radiographs were included and stratified in two cohorts: inf...

journal_title：Clinical rheumatology

authors： Camerer M,Ehrenstein B,Hoffstetter P,Fleck M,Hartung W

更新日期：2017-09-01 00:00:00

abstract：:Fibromyalgia syndrome (FMS) is characterized by chronic widespread pain and systemic symptoms. The aetiology and pathogenesis of fibromyalgia are not yet fully understood. Blood neutrophil/lymphocyte ratio (NLR) is a marker of systemic inflammatory response. Platelet distribution width (PDW) and mean platelet volume (...

journal_title：Clinical rheumatology

authors： Aktürk S,Büyükavcı R

更新日期：2017-08-01 00:00:00

abstract：:Primary knee osteoarthritis (OA) contributes to disability among middle-aged and elderly people. Dickkopf-1 (Dkk-1) and sclerostin are inhibitors of Wnt/β-catenin signaling pathway implicated in regulation of cartilage homeostasis and bone formation, respectively. We aim to investigate the association between the seru...

journal_title：Clinical rheumatology

authors： Theologis T,Efstathopoulos N,Nikolaou V,Charikopoulos I,Papapavlos I,Kokkoris P,Papatheodorou A,Nasiri-Ansari N,Kassi E

更新日期：2017-08-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) are the key enzymes responsible for the joint destruction. Their activity is regulated by the level of proinflammatory cytokines. The aim of this study was to examine the impact of TNF-α G-308A polymorphism on MMP-9 levels in blood plasma (BP) and synovial fluid (SF) of patients with r...

journal_title：Clinical rheumatology

authors： Stojanovic S,Bojana Stamenkovic,Stoimenov TJ,Nedovic J,Zivkovic V,Despotovic M,Pavlovic D

更新日期：2017-07-01 00:00:00

abstract：:The study aimed to determine whether unique clinical patterns of AS may exist in China, specifically to explore the different clinical manifestations caused by gender, HLA-B27 status, and age at disease onset. The multicenter cross-sectional survey was conducted and 1251 patients were enrolled across China, representi...

journal_title：Clinical rheumatology

authors： Qian Q,Xu X,He H,Ji H,Zhang H,Ding Y,Dai SM,Zou Y,Zhu Q,Yang C,Ye S,Jiang L,Tang JP,Tong Q,He D,Zhao D,Li Y,Ma Y,Zhou J,Yuan Z,Zhang J,Jin L,Zhou X,Reveille JD,Zou H,Wang J

更新日期：2017-07-01 00:00:00

abstract：:The aims of this study were to determine whether placebo treatment in randomised controlled trials (RCTs) is effective for fibromyalgia and to identify possible determinants of the magnitude of any such placebo effect. A systematic literature search was undertaken for RCTs in people with fibromyalgia that included a p...

journal_title：Clinical rheumatology

authors： Chen X,Zou K,Abdullah N,Whiteside N,Sarmanova A,Doherty M,Zhang W

更新日期：2017-07-01 00:00:00

abstract：:Knee osteoarthritis is a common joint problem leading to an increase of pain and a loss of function in older individuals. The main objective of this study was to evaluate if a participant who was randomly assigned to his preferred group improved his adherence to an effective walking program compared to a participant w...

journal_title：Clinical rheumatology

authors： Loew L,Brosseau L,Kenny GP,Durand-Bush N,Poitras S,De Angelis G,Wells GA

更新日期：2017-07-01 00:00:00

abstract：:Interstitial lung disease (ILD) is a severe rheumatoid arthritis (RA) manifestation. The worst survival has been associated with usual interstitial pneumonia (UIP) definitive pattern in high-resolution chest tomography (HRCT) scans. Moreover, the use of methotrexate in RA-ILD is controversial. Our aim was to evaluate ...

journal_title：Clinical rheumatology

authors： Rojas-Serrano J,Herrera-Bringas D,Pérez-Román DI,Pérez-Dorame R,Mateos-Toledo H,Mejía M

更新日期：2017-07-01 00:00:00

abstract：:Primary Sjögren syndrome (pSS)-related interstitial lung disease (ILD) involved about 10-20% of patients. In 20% of cases, ILD can be diagnosed before pSS; anyway, few studies have investigated the frequency of ILD as the first clinically relevant manifestation of pSS, generally referred to retrospective studies. Aim ...

journal_title：Clinical rheumatology

authors： Manfredi A,Sebastiani M,Cerri S,Cassone G,Bellini P,Casa GD,Luppi F,Ferri C

更新日期：2017-06-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease causing joint damage and significant functional impairment. Methotrexate (MTX) remains the mainstay for the treatment of RA. MTX inhibits several enzymes of the folate and nucleotide pathways. Thymidylate synthase (TYMS) is an important enzyme in the d...

journal_title：Clinical rheumatology

authors： Muralidharan N,Misra DP,Jain VK,Negi VS

更新日期：2017-06-01 00:00:00

abstract：:The levels of 63 cytokines, chemokines, and growth factors were measured in the serum of four patients with idiopathic morphea and of one patient with vitamin K1-induced morphea employing a multiplex assay to identify the role of inflammatory/immunologic events in their pathogenesis. Full-thickness skin biopsies of af...

journal_title：Clinical rheumatology

authors： Cox LA,Webster GF,Piera-Velazquez S,Jimenez SA

更新日期：2017-05-01 00:00:00

abstract：:Beliefs about the unacceptability of experiencing and expressing emotions have been found to be related to worse outcomes in people with persistent physical symptoms. The current study tested mediation models regarding emotional suppression, beliefs about emotions, support-seeking and global impact in fibromyalgia. On...

journal_title：Clinical rheumatology

authors： Bowers H,Wroe AL,Pincus T

更新日期：2017-05-01 00:00:00

abstract：:Reduced physical function and health-related quality of life are common in rheumatoid arthritis (RA), and further studies are needed that examine novel determinates of reduced physical function in RA. This study examines whether frailty, a state of increased vulnerability to stressors, is associated with differences i...

journal_title：Clinical rheumatology

authors： Andrews JS,Trupin L,Yelin EH,Hough CL,Covinsky KE,Katz PP

更新日期：2017-05-01 00:00:00

abstract：:The objective of the study was to analyze the impact of TNF antagonists (TNFa) on the total cholesterol and triglycerides on ankylosing spondylitis (AS) and psoriatic arthritis (PsA). In this single-centre observational study of AS and PsA patients, differences in triglyceride and total cholesterol levels and frequenc...

journal_title：Clinical rheumatology

authors： Maneiro JR,Souto A,Gomez-Reino JJ

更新日期：2017-05-01 00:00:00

abstract：:Despite improved quality of care for rheumatoid arthritis (RA) patients, many still experience treatment failure with a biologic agent and eventually switch to another biologic agent. We investigated patterns of biologic treatment and reasons for switching biologics in patients with RA. Patients with RA who had starte...

journal_title：Clinical rheumatology

authors： Park DJ,Choi SJ,Shin K,Kim HA,Park YB,Kang SW,Kwok SK,Kim SK,Nam EJ,Sung YK,Lee J,Lee CH,Jeon CH,Lee SS

更新日期：2017-05-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is associated with increased vascular calcification, although the rate of progress of calcification is uncertain. The aim of the study was to evaluate the progression of and the predictors for calcification in different vascular beds over 10 years. The 10-year actual coronary calcium score (C...

journal_title：Clinical rheumatology

authors： Liu JH,Ng MY,Cheung T,Chung HY,Chen Y,Zhen Z,Zou Y,Mak KF,Khong PL,Lau CS,Tse HF,Yiu KH

更新日期：2017-04-01 00:00:00

abstract：:Functional limitation is often complained by patients with ankylosing spondylitis (AS). With a rising number of patients suffering from AS, there are a limited number of reports focusing on functional limitation of AS in Chinese patients. This study was conducted to investigate the level of functional limitation and e...

journal_title：Clinical rheumatology

authors： Song Y,Wang C,Chen H

更新日期：2017-04-01 00:00:00

abstract：:To clarify the roles of neutrophils in anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitic neuropathy, we studied neutrophil extracellular traps (NETs) in peripheral nerve vasculitis. Stored nerve samples from 17 patients with microscopic polyangiitis (MPA) were immunohistochemically analyzed using a...

journal_title：Clinical rheumatology

authors： Takeuchi H,Kawasaki T,Shigematsu K,Kawamura K,Oka N

更新日期：2017-04-01 00:00:00

abstract：:Renal involvement in systemic lupus erythematosus (SLE) is common and has been associated with an increased risk of mortality [1]. Early diagnosis is imperative to control proteinuria and prevent the progression to end-stage renal disease. Standard induction therapies include cyclophosphamide (CYC) and mycophenolate m...

journal_title：Clinical rheumatology

authors： Raturi R,Patel AA,Carter JD

更新日期：2017-03-01 00:00:00

abstract：:Coexistence of rheumatoid arthritis and gout is considered to be unusual. The current study was designed as a population-based cross-sectional study, utilizing the medical database of Clalit Health Services, the largest healthcare provider organization in Israel. Data of adult patients who were previously diagnosed wi...

journal_title：Clinical rheumatology

authors： Merdler-Rabinowicz R,Tiosano S,Comaneshter D,Cohen AD,Amital H

更新日期：2017-03-01 00:00:00

abstract：:To compare rheumatologists' adherence to treatment protocols for rheumatoid arthritis (RA) targeted at Disease Activity Score (DAS) ≤2.4 or <1.6. The BeSt-study enrolled 508 early RA (1987) patients targeted at DAS ≤2.4. The IMPROVED-study included 479 early RA (2010) and 122 undifferentiated arthritis patients target...

journal_title：Clinical rheumatology

authors： Akdemir G,Markusse IM,Goekoop-Ruiterman YP,Steup-Beekman GM,Grillet BA,Kerstens PJ,Lems WF,Huizinga TW,Allaart CF

更新日期：2017-02-01 00:00:00

abstract：:The aim of this study was to investigate the association of two common interleukin 12B (IL-12B) polymorphisms (rs3212227 and rs6887695) with rheumatoid arthritis (RA) susceptibility through meta-analyses. A systematic literature search of PubMed, Web of Science, Cochrane Library, and Embase databases was conducted on ...

journal_title：Clinical rheumatology

authors： Yang X,Xiao F,Luo D,Wang G,Liang S

更新日期：2017-02-01 00:00:00

abstract：:Juvenile dermatomyositis (JDM) is a rare chronic inflammatory disease of unknown etiology and primarily involves muscle and skin. It is the most common idiopathic inflammatory myopathy of childhood. This study aimed to evaluate demographic and clinical features, laboratory data, treatment modalities, and outcome of pa...

journal_title：Clinical rheumatology

authors： Barut K,Aydin PO,Adrovic A,Sahin S,Kasapcopur O

更新日期：2017-02-01 00:00:00